Presence ofMacroalbuminuria Predicts Severe Hypoglycemia in PatientsWith Type 2 DiabetesMellitus A 10-year follow-up study
نویسنده
چکیده
RESEARCH DESIGN AND METHODSdFrom January 2000 to December 2002, patients with type 2 diabetes aged 25–75 years without chronic kidney disease (estimated glomerular filtration rate $60 mL/min/1.73 m) were consecutively recruited (n = 1,217) and followed-up in January 2011 and May 2012. Severe hypoglycemia (SH) was defined as an event requiring the assistance of another person to actively administer glucose, hospitalization, or medical care in an emergency department. We used Cox proportional hazard regression analysis to test the association between SH episodes and potential explanatory variables.
منابع مشابه
Cardiovascular autonomic dysfunction predicts severe hypoglycemia in patients with type 2 diabetes: a 10-year follow-up study.
OBJECTIVE The aim of this study was to investigate the development of severe hypoglycemia (SH) in the presence of cardiovascular autonomic neuropathy (CAN) in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS From January 2001 to December 2002, a total of 894 patients with type 2 diabetes were enrolled. A cardiovascular autonomic function test (AFT) was performed using the following he...
متن کاملLong-Term Efficacy and Safety of Linagliptin in PatientsWith Type 2 Diabetes and Severe Renal Impairment A 1-year, randomized, double-blind, placebo-controlled study
RESEARCH DESIGN AND METHODSdIn this 1-year, double-blind study, 133 patients with type 2 diabetes (HbA1c 7.0–10.0%) and severe RI (estimated glomerular filtration rate [eGFR],30 mL/min/1.73 m) at screening were randomized to linagliptin 5 mg (n = 68) or placebo (n = 65) once daily, added to existing background therapy. The primary efficacy end point was HbA1c change from baseline to week 12. Ef...
متن کاملPresence of Macroalbuminuria Predicts Severe Hypoglycemia in Patients With Type 2 Diabetes
OBJECTIVE We investigated the factors that might influence the development of severe hypoglycemia in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS From January 2000 to December 2002, patients with type 2 diabetes aged 25-75 years without chronic kidney disease (estimated glomerular filtration rate ≥60 mL/min/1.73 m(2)) were consecutively recruited (n = 1,217) and followed-up in J...
متن کاملSevere hypoglycemia and cognitive decline in older people with type 2 diabetes: the Edinburgh type 2 diabetes study.
OBJECTIVE People with type 2 diabetes are at increased risk of age-related cognitive decline and dementia. Hypoglycemia is a candidate risk factor, but the direction of association between episodes of severe hypoglycemia and cognitive decline in type 2 diabetes remains uncertain. RESEARCH DESIGN AND METHODS In the Edinburgh Type 2 Diabetes Study, cognitive function was assessed in 831 adults ...
متن کاملBlood glucose awareness training (BGAT-2): long-term benefits.
OBJECTIVE Blood glucose awareness training (BGAT) has been shown to improve awareness of blood glucose (BG) fluctuations among adults with type 1 diabetes. This study investigates the long-term (12-month) benefits of BGAT-2. RESEARCH DESIGN AND METHODS A total of 73 adults with type 1 diabetes participated in a 6-month repeated baseline design with a 12-month follow-up. At 6 months and 1 mont...
متن کامل